These, along with recombinant platelet-derived growth factor, are now considered to be the benchmark for biological therapies. These include dermal skin substitute and allogenic bilayered human skin. 21.10.1.6 Bioengineered cell-based therapies Studies so far show that no one single biological dressing is clearly superior among all the biological dressings. This increase in available dressings for use in the diabetic foot is positive however, there is no evidence yet to guide us as to which dressing is best to use. These effects can prevent degradation of the matrix that is present and simultaneously increase collagen and granulation tissue formation. These agents can help reduce inflammatory cytokines and proteases while increasing growth factors. They can comprise collagen, extracellular matrix proteins, chitosan, fibrin, hyaluronic acid, and elastin. They can release therapeutic agents such as growth factors, peptides, and stem cells. These are aimed at rebuilding the extracellular matrix. These help to maintain a moist environment and are ideal for use on chronic wounds. These include hydrogels, alginates, hydrocolloids, silver, and biological dressings. This has been shown to be an effective aid in the debridement and promotion of wound healing that can be applied to the diabetic. It uses a high-pressure jet stream of normal saline to do this and has proven to be a very quick and effective method of debridement. This is a new effective tool that cuts and debrides tissue in a thin layer while simultaneously aspirating it away. 21.10.1.2 The Versajet hydrosurgery system (Smith & Nephew) They can therefore be an effective adjunct to surgical debridement. The larvae debride dead tissue and their secretions target both Gram-negative and Gram-positive bacteria. Larval therapy to debride and disinfect has been used for chronic wounds which are difficult to heal. The new debridement methods and wound healing strategies are evolving although the use of scalpel and scissors for debridement remains the benchmark in the management of diabetic foot ulcers. AgriProtein claims to produce over three thousand tons of fatty-acid oil as a byproduct and sixteen tons of frass, or fly droppings per plant, which can be used as a valuable fertilizer.Martin Jervis Nsubuga, Claude Pierre-Jerome, in The Essentials of Charcot Neuroarthropathy, 2022 21.10.1 New debridement methods It is also possible to extract insect fat, protein ( for human consumption), and chitin. AgriProtein, a British company specializing in insect protein production, is pushing for more international business, claiming to hold the potential to shift the fish feed market away from energy expensive fish farming. The maggots are often sold and used as animal feed: in particular, for fish, chickens, pigs, and ducks. Food (waste) is then inserted and left into the top bin, where the flies will lay their eggs and produce maggots, shifting and separating into the bottom bin. The bottom bin having a large hole cut on top, while the top having smaller, filtered holes on the bottom. An alternative method can be seen used more commonly in small scale applications, such as two trash bins stacked on top of each other. The maggots are then harvested and the leftover is discarded or further processed (e.g., bones can be ground to bone meal). After that, the bins are filled with water, so the maggots start to float (separating themselves from any leftovers). Then, flies deposit eggs on the offal and meat, and maggots hatch and consume it. The bins are then covered with chicken wire to prevent any large animals from feeding. When using indigenous fly species, one tactic (employed by the Songhai Center in Benin) is to simply dump offal or meat that has exceeded the sell-by date in concrete bins. Due to convenience, fly species are often used which are indigenous to the area of cultivation. It is distinct from vermicomposting, as there is no separate composting process occurring and maggots are used to consume flesh, rather than earthworms to consume plant-based materials.Ī variety of species can be used, including the black soldier fly. Maggot farming is the act of growing maggots for industry.
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